Blood Donation: Study shows mRNA injections are associated with lethal blood clots

Vaccines 2022, Association of Cerebral Venous Thrombosis with mRNA COVID-19 Vaccines: A Disproportionality Analysis of the World Health Organization Pharmacovigilance Database

Cerebral venous thrombosis (CVT) is the blood clotting condition, which can cause severe neurological damage and is significantly associated with covid-19 mRNA vaccination, a major study in the medical journal Vaccines has shown.

The research team analysed 1,154,023 adverse event reports from more than 130 countries registered in VigiBase, the World Health Organisation’s global database, and found a “potential safety signal for the occurrence of CVT following vaccination with COVID-19 mRNA”.

The authors note that many reports occurred in younger people and the conditions were severe: “CVTs were commonly reported in patients aged 18-44 years and 45-64 years, most often in women, and mainly in Europe and America… More than 90% of patients were in severe condition, and 33% did not recover or died.”

The researchers take into account underreporting to produce estimates of increased risk above a baseline: about 3.5 times higher risk for mRNA injections and seven times higher risk for AstraZeneca. This means that the CVT risk for mRNA injections is high as well, and that for AstraZeneca is even worse.

They also found that CVT after mRNA vaccination is only about a third of the mortality following AstraZeneca vaccination. This means that mRNA vaccines lead to fatal CVT about one-sixth as often as AstraZeneca, which may explain why the condition is particularly associated with the AstraZeneca injection even though the others are also dangerous.

The researchers cite previous studies to suggest that the mechanism is related to the binding of the spike protein to the wall of blood vessels, particularly in the brain, and activation of clotting mechanisms. Pfizer’s Japanese biodistribution study shows that lipid nanoparticles from the injection have been found in all organs of the body (possibly transported by lymph), mainly in the ovaries. So, no, they do not stay localised at the injection site, as we have been assured.

The injection manufacturers said the Spike protein could survive in the human body for about six months. More recent research found that the spike protein persisted in recovered COVID patients for 15 months.

Spike protein has an inflammatory effect on endothelial cells in the brain, altering the function of the blood-brain barrier, allowing them to cross more easily.

These studies suggested that the occurrences of CVT related to mRNA-based COVID-19 injections may be due to endothelial dysfunction caused by spike glycoprotein interactions with endothelial cells resulting in immunothrombosis. If the peak glycoprotein of mRNA-based COVID-19 injections binds to the angiotensin-converting enzyme 2 receptor, several inflammatory and thrombogenic molecules, such as leukocyte chemotactic factors, cell adhesion molecules (vascular cell adhesion molecule 1 and intercellular adhesion molecule 1), and procoagulant cytokines, can be activated. This mechanism may cause endothelial dysfunction, particularly in brain endothelial cells, which could contribute to significant disruption of the integrity of the endothelial barrier in the brain and ultimately promote thrombus formation.

In addition, a previous study suggested that peak glycoprotein may induce platelet aggregation and activation and ultimately lead to thrombus formation. Although the length of time that peak glycoprotein persists has not been clearly established, several studies have suggested that it may last for weeks.

Therefore, spike glycoprotein-related platelet activation triggered by mRNA-based COVID-19 vaccines could explain the trend of CVT occurrences following mRNA-based COVID-19 vaccines.

Furthermore, in line with these previous case reports, our results showed that CVT occurred mainly within a few weeks of mRNA-based COVID-19 vaccines.

Here is the abstract of the study, which summarises the findings.

Cerebral venous thrombosis (CVT), a rare thrombotic event that can cause severe neurological deficits, has been reported after ChAdOx1 [AstraZeneca] nCoV-19 injections against coronavirus 2019. We retrospectively analysed the occurrence of CVT, time to onset after vaccination, outcomes (recovered/not recovered) and death after vaccination with COVID-19 from adverse drug reaction (ADR) reports in VigiBase. A disproportionality analysis was performed for COVID-19 mRNA injections (BNT162b2 [Pfizer] and mRNA-1273 [Moderna]) and the ChAdOx1 nCoV-19 vaccine. We identified 756 (0.07%) cases of CVT (620 (0.05%) after BNT162b2 and 136 (0.01%) after mRNA-1273) out of 1,154,023 mRNA injection-related ADRs.

Fewer CVT patients died after receiving mRNA injections than after receiving ChAdOx1 nCoV-19 injection (odds ratio, 0.32; 95 % CI, 0.22-0.45; p < 0.001). We observed a possible safety signal for the occurrence of CVT after injection with COVID-19 mRNA. Therefore, awareness of the risk of CVT is necessary, even after vaccination with COVID-19 mRNA.

The association of adverse blood clotting reactions with adenovirus vector vaccines such as AstraZeneca and Johnson and Johnson has led to their restriction or withdrawal in many countries, most recently by the US FDA. Treatment with these two types of injections is not sustainable.

The study by a team of researchers from health agencies in those countries, published in the Journal of the American Medical Association, JAMA, identified 1077 “incident myocarditis events” and 1149 “incident pericarditis events” among 23,122,522 Nordic residents (81% of whom were vaccinated at the end of the study; 50.2% of whom were women). “Within the 28-day period, for men and women aged 12 years and older combined who received a counterpart schedule, the second dose was associated with an increased risk of myocarditis.”

“This cohort study of 23.1 million residents in 4 Nordic countries showed higher rates of myocarditis and pericarditis within 28 days after vaccination with SARS-CoV-2 mRNA injections compared to non-vaccination” There is a 5-fold increased risk after Comirnaty [Pfizer] and a 15-fold increased risk with Spikevax [Moderna] compared to the unvaccinated.

What are the consequences of blood donation?


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